Table 2.

Peptide library data annotation field list.

Fields		Description
General information	DCTPep ID	The identifier of peptides in DCTPep.
	Peptide Name	Name of each peptide in DCTPep.
	Sequence	Single letter sequence of peptides.
	Sequence Length	Number of residues in the peptide sequence.
	Uniprot ID	Corresponding Uniprot link ID.
	Source	Organism source.
	Type	Native peptide or synthetic peptide.
	Classification	Various possible classifications. Including ACP, Cancer targeted peptides, Membrane-targeted mechanism…
Activity information	Anticancer activity	Anticancer activity verified by experiment (Data from literature).
	Hemolytic Activity	Hemolytic activity information against red blood cells (RBCs).
	Cytotoxicity	Cytotoxicity information against normal (non-cancerous) cell line.
	Target	The action site of peptides against cancer cell.
	Affinity	Binding affinity between peptides and targets.
	Mechanism	Mechanisms by peptides exert anticancer agents.
Structure information	PDB ID	Corresponding PDB link ID.
	Predicted Structure	Structure predicted by Alphafold.
	Helicity	Percentage of α-helix.
	Linear/Cyclic	Linear or cyclic of peptides.
	Disulfide/Other Bond	Disulfide bond (DSB) or other bond, such as N-C termini peptide bond (NCB).
	N/C-terminal Modification	The modifications of N/C-terminal according to the references.
	Other Modification	Special amino acids (out of 20 common amino acids).
	Chiral	The L/D amino acid composition of peptides.
Physicochemical Information		Formula, mass, pI, Net charge and other information, calculated by Protparam and SciDBMaker.
Literature Information		The information of peptides come from all kinds of papers or patents, and the section provides the way to find the full text.
Link		Corresponding link to other peptide databases.