Table 3.  Recovery from secondary adrenal insufficiency after ACTH therapy .

Study	Ross et al.11	Rao and Willis13	Mytinger et al.7	Sakaguchi et al.8
Number of patients in whom
adrenal function recovery was
confirmed using stimulation tests	1	1	1	3
Adrenal stimulation test
Stimulation agent	insulin	metyrapone	ACTH	CRH
Timing of re-exam	6 wks#1	2 mo#1	8 mo#1, 2	61, 161, 255 days#3
The result of re-exam	normal	normal	normal	normal in all cases

#1: Interval between first examination and re-examination.

#2: Physiological replacement hydrocortisone was slowly tapered for about 7 months, repeat adrenal stimulation test was conducted 1 month after weaning off hydrocortisone.

#3: After ACTH therapy completion.