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. 2024 Mar 5;9(7):e169830. doi: 10.1172/jci.insight.169830

Figure 1. CD93, MMRN2, and fibronectin are highly expressed in the blood vessels of primary tumors and metastases.

Figure 1

(A) Immunohistochemical staining of CD93, MMRN2, and fibronectin in human tissue microarrays of primary lung cancer (n = 60), metastases originating from lung cancer (n = 50), and melanoma metastases (n = 20). Scale bars: 100 μm. Graphs represent the average of a semiquantitative scoring of CD93+ (B), MMRN2+ (C), and fibronectin+ (D) vessels performed in tumor cores of each patient by 2 researchers in a blinded fashion on a scale of 0 to 2 (0 = no vessel staining, 1 = medium intensity, and 2 = high intensity). Lung p., lung primary tumors; Lung c.m., lung cancer metastases; Mel.m., melanoma metastases.