Table 1.
Effects of GLP-1R agonists on nicotine-mediated behaviors and neurochemical responses.
| Study | Sex/strain/species | Model | GLP-1R agonist pretreatment | Route of admin | Results |
|---|---|---|---|---|---|
| Egecioglu et al. [87] | Male NMRI mice | Nicotine-induced locomotor activation | Acute Exendin-4 (0 or 2.4 μg/kg) | i.p. | Attenuated nicotine-induced locomotor activation |
| “ | Nicotine-evoked dopamine release | Acute Exendin-4 (0 or 2.4 μg/kg) | i.p. | Attenuated nicotine-evoked dopamine release in the NAc | |
| “ | Expression of nicotine CPP | Acute Exendin-4 (0 or 2.4 μg/kg) | i.p. | Blocked expression of CPP | |
| “ | Expression of nicotine-induced locomotor sensitization | Acute Exendin-4 (0 or 2.4 μg/kg) | i.p. | Attenuated expression of locomotor sensitization | |
| Tuesta et al. [39] | Male C57BL6/J mice | Nicotine IVSA (0.1 mg/kg/infusion) | Acute Exendin-4 (0 or 10 μg/kg) & sitagliptin (0 or 10 mg/kg) | i.p. | Attenuated nicotine self-administration |
| Male Wistar rats | Nicotine IVSA (0.03 mg/kg infusion) | Acute Exendin-4 (0 or 0.1 μg/0.5 μl/hemisphere) | intra-IPN | Attenuated nicotine self-administration | |
| “ | Change in ICSS threshold after nicotine IVSA | Acute Exendin-4 (0 or 0.1 μg/0.5 μl/hemisphere) | intra-IPN | Prevented nicotine-induced changes in ICSS thresholds | |
| Herman et al. [38] | Male and female Sprague Dawley rats | Nicotine IVSA (0.03 mg/kg/infusion) | Acute liraglutide (0 or 25 μg/kg) | i.p. | Attenuated nicotine self-administration |
| “ | Extinction of nicotine taking | Repeated liraglutide (0 or 25 μg/kg) | i.p. | Decreased days to extinguish | |
| “ | Drug + cue-induced reinstatement of nicotine seeking | Repeated liraglutide (0 or 25 μg/kg) | i.p. | Attenuated nicotine seeking during withdrawal | |
| Falk et al. [95] | Male NMRI mice | Nicotine-evoked dopamine release | Acute Liraglutide (0 or 10 nmol/kg) | s.c. | Attenuated nicotine-evoked dopamine release in the NAc |
i.p. = intraperitoneal; CPP = conditioned place preference; IVSA = intravenous self-administration; ICSS = intra-cranial self-stimulation; IPN = interpeduncular nucleus; s.c. = subcutaneous; NAc = nucleus accumbens.