Fig. 6.

Notch signaling pathway in cancer metabolic reprogramming. Notch signaling plays a crucial role in the metabolic reprogramming of cancer cells, particularly during the glycolytic switch. The Notch pathway is active during this transition in cancer cells, with several genes directly regulated as transcriptional targets. This regulation mediates the shift in cellular metabolism towards the Warburg effect. (Figure created using BioRender.com). CLL chronic lymphocytic leukemia, PTEN phosphatase and tensin homolog, T-ALL T cell acute lymphoblastic leukemia, PI3K/AKT phosphoinositide 3-kinase/protein kinase B, HIF1α hypoxia-inducible factor 1α, Co-A coactivator, MAML mastermind-like, CSL CBF1/suppressor of hairless/Lag1, GLUT glucose transporters, MCT monocarboxylate transporter, ATP adenosine triphosphate, NADH nicotinamide adenine dinucleotide hydride, NAD nicotinamide adenine dinucleotide, TCA tricarboxylic acid, α-KG alpha-ketoglutarate