Fig. 8.

Notch signaling pathway in chemoresistance. The aberrant expression and overactivation of Notch pathway components play crucial roles in contributing to chemoresistance. (Figure created with BioRender.com). PDAC pancreatic ductal adenocarcinoma, N1DARP Notch1 degradation-associated regulatory polypeptide, N1ICD Notch1 intracellular domain, CHEMO chemotherapy, SCLC small cell lung cancer, AP-1 activator protein-1, LUAD lung adenocarcinoma, MVP major vault protein, AKT protein kinase B, TNBC triple-negative breast cancer, ADAM a disintegrin and metalloprotease, JAG1-ICD Jagged1 intracellular domain, CRC colorectal cancer