Table 1.
Traditional coagulation tests and thrombin generation.
| Value | Reference range | |
|---|---|---|
| Prothrombin time, PT (%) | 80.4 | 70–100 |
| International normalized ratio, INR | 1.11 | – |
| Activated partial thromboplastin time, aPTT (sec) | 30.7 | 22.8–31.0 |
| FXI (%) | 80.6 | 80–120 |
| FX (%) | 83.6 | 80–120 |
| FIX (%) | 88.2 | 80–120 |
| FVIII (%) | 119.6 | 60–120 |
| FII (%) | 84.9 | 80–120 |
| Fibrinogen (mg/dl) | 238 | 150–450 |
| Antithrombin (%) | 83.3 | 80–120 |
| Protein C coagulometric activity (%) | 80.9 | 80–120 |
| Protein C chromogenic activity (%) | 85.7 | 80–120 |
| Protein C antigen (%) | 84 | 80–120 |
| Protein S coagulometric activity (%) | 81.6 | 70–130 |
| Protein S free antigen (%) | 102 | 80–120 |
| Protein S total antigen (%) | 91 | 80–120 |
| Plasminogen activity (%) | 73.6 | 75–140 |
| Plasminogen activator inhibitor-1 antigen (ng/ml) | 11.6 | 1.0–25.0 |
| Alpha2-antiplasmin (%) | 80.9 | 80–120 |
| aPTT—Lupus Anticoagulant (sec) | 33.7 | 32.0–43.0 |
| dRVVT (sec) | 32.8 | 26.0–45.0 |
| Anticardiolipin antibodies IgG (U/ml) | 1.2 | <10 |
| Anticardiolipin antibodies IgM (U/ml) | 2.3 | <10 |
| Anti-beta-2 glycoprotein 1 IgG (U/ml) | 1.4 | <8 |
| Anti-beta-2 glycoprotein 1 IgM (U/ml) | 2.0 | <8 |
| APC sensitivity ratio | 3.71 | >2.00 |
| APC sensitivity ratio normalization | 1.23 | >0.84 |
| FV Leiden mutation | Wild type | – |
| Prothrombin G20210A variant | Wild type | – |
| Thrombin Generation | ||
| ETP (nM*min) | 1,525 | 1,374–1,804 |
| ETP + TM (nM*min) | 893 | 755–1,138 |
| Peak (nM) | 182.9 | 175.6–228.9 |
| Peak + TM (nM) | 119.9 | 109.6–132.7 |
| Lag time (min) | 3.7 | 3.2–4.3 |
| Lag time + TM (min) | 5.7 | 5.1–6.5 |
| Time to peak (min) | 8.8 | 8.3–10.0 |
| Time to peak + TM (min) | 9.9 | 9.5–11.5 |
| Vel index (nM/min) | 38.0 | 29.3–39.7 |
| Vel index + TM (nM/min) | 28.2 | 24.5–37.6 |
dRVVT, diluted Russel viper venom time; APC, activated protein C; ETP, endogenous thrombin potential; TM, thrombomodulin, Vel, velocity.