Figure 10.

CellChat analysis of the communications between T cell subsets. (A) Circle plots illustrating the number and strength of interactions between T cell subsets in HC and HFRS group. (B,C) Identification of singling roles for cells using network centrality analysis. (D) The Sankey diagram of signaling pathways in different patterns for various cell types in the HC and HFRS groups. The left panel illustrates how cells coordinate with each other as signal senders and how they coordinate with certain signaling pathways to drive communication under outgoing patterns. The right panel illustrates how cells coordinate with each other as signal receivers and how they coordinate with certain signaling pathways to respond to incoming signals under incoming-patterns. The thickness of the flow indicates the contribution of the cell group or signaling pathway to each latent pattern. (E) Violin plot showing the expression distribution of signaling genes involved in the inferred signaling network between normal and HFRS group.