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. 2024 May 13;11:1403335. doi: 10.3389/fmed.2024.1403335

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Copyright © 2024 Xiao, Lin, Liu and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characteristics of HFRS Immunological Repertoire (BCR Repertoire). (A) Comparison of clone count in the BCR repertoire. Clonotypes are defined based on the nucleotide sequence of the CDR3 region. Each CDR3 sequence defines a unique clonal population. (B) Comparison of clonal space equilibrium. Clonal space equilibrium analysis relative abundance, also known as clonal space equilibrium, is defined as the proportion of the library occupied by clonal populations with specific abundances. (C) Distribution of BCR CDR3 amino acid sequence lengths in HFRS and HC groups. (D) Differential comparison of clonotype diversity index Chao1. (E) Differential comparison of clonotype diversity index inverse Simpson index. (F) Comparison of IGHV gene usage. (G) Comparison of IGHJ gene usage. (H) Clonotype tracking in HFRS samples. Mean target values, error target values, standard errors, and p-values were obtained using the Wilcoxon test.