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. 2024 May 13;11:1403335. doi: 10.3389/fmed.2024.1403335

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Copyright © 2024 Xiao, Lin, Liu and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characteristics of Innate Immune Cells in the HC and HFRS Groups. (A) The bubble plot illustrates the expression levels and expression percentages of the top 70 differentially expressed genes (DEGs) in each cell subtype. The size of each bubble corresponds to the percentage of expression in the cell, while the color represents its expression level. (B) Box plots are used to visualize the cell state scores of genes associated with innate immune response regulation in various cell subtypes. The box plots are divided into two different groups: HC and HFRS. They describe the comparison of cell state scores between the two groups. Each condition is represented by a different color, and the y-axis represents the median. (C) The plot illustrates the differentially expressed genes (DEGs) between the two groups in various cell subtypes, and marks the top five upregulated or downregulated genes based on the absolute value of Log2Foldchange. (D) KEGG enrichment analysis of the DEGs in CD16 monocytes and NK cells was conducted using the KEGG database.