Figure 6.

DEGs in T cells in the HC and HFRS groups. (A) The UMAP visualization of distinct populations of Central memory CD4 + T cells, Effector CD4+ T cells, Effector CD8+ T cells (GNLY), Effector CD8+ T cells (GZMH), Effector CD8+ T cells (GZMK), Naive CD4+ T cells, Naive CD8+ T cells Effector memory CD4+ cells, Tissue resident memory CD8+ T cells and Type 1 helper T like cells depicted. Additional cell clusters are denoted as “other cells.” Each data point represents an individual cell, and its color signifies the cell type. (B) The UMAP visualization of T cell subset acquired from the HC group (n = 2) and the HFRS group (n = 6) is depicted. Each data point corresponds to a distinct cell, with its color denoting the specific cell type. (C) The bubble plot illustrates the expression levels and expression percentages of the top 70 differentially expressed genes (DEGs) in each cell subtype. The size of each bubble corresponds to the percentage of expression in the cell, while the color represents its expression level. (D) Enrichment analyses of the DEGs were performed using the BP database within the GO. The GO terms are annotated with their respective names and IDs, and are arranged in descending order based on the logarithm of the reciprocal of the p value (−log10). The top 20 enriched GO terms are displayed. (E) Enrichment analyses of the KEGG were performed. The top 20 enriched GO terms are displayed. (F) The plot illustrates the differentially expressed genes (DEGs) between the two groups in various cell subtypes, and marks the top five upregulated or downregulated genes based on the absolute value of Log2Foldchange.