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. 2024 May 13;11:1403335. doi: 10.3389/fmed.2024.1403335

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Copyright © 2024 Xiao, Lin, Liu and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identifcation of gene co-expression modules among B cells. (A) Unsupervised clustering and annotation of cell types in Healthy and Sepsis samples. (B) Power value equal to 8 when the network reached a scale-free distribution. (C) Highly variable genes were clustered into 20 modules through hdWGCNA. (D) Dot plot for enrichment of modules in different cell types. (E) Dot plot for enrichment of modules in different groups. (F) UMAP of the expression of B cells -M20 among all cells. (G) The protein–protein interaction network illustrates the interactions within the B cell module M20, with the top three hub genes showing the most interactions highlighted in the graph. (H) Dot plot of the GO functional enrich analysis of the module B cells -M20.