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Start of tolvaptan: Serum sodium, urine osmolality, urine output, and volume/solute management. Summary of critical data before and after the start of tolvaptan. Within a few hours after the first dose of tolvaptan, the urine volume increased, paralleled by a drop in urine osmolarity from 813 to 50 mOsm/kg, and substitution of electrolyte-free water (glucose 5%) was started at a serum sodium concentration of 124 mmol/l to prevent too fast correction of hyponatremia.
