Table 2.
Associations with spontaneous preterm birth.
| only samples <16 weeks of gestation |
all samples |
|||||||
|---|---|---|---|---|---|---|---|---|
| univariate |
multivariatea |
univariate |
multivariatea |
|||||
| OR | 95 % CI | OR | 95 % CI | OR | 95 % CI | OR | 95 % CI | |
| Microbiota | ||||||||
| CST I | ref | Ref | ||||||
| CST II | 1.8 | 0.4–6.8 | 1.6 | 0.4–6.1 | 2.3 | 0.8–5.9 | 2.1 | 0.8–5.6 |
| CST III | 0.5 | 0.1–1.8 | 0.5 | 0.1–1.8 | 1.0 | 0.5–2.1 | 1.0 | 0.5–2.2 |
| CST IV | 1.4 | 0.5–4.0 | 1.4 | 0.5–4.0 | 1.7 | 0.8–3.8 | 1.8 | 0.8–3.9 |
| CST V | 0.4 | <0.1–4.4 | 0.4 | <0.1–4.0 | 0.3 | <0.1–2.6 | 0.3 | <0.1–2.6 |
| Gardnerella species detection | ||||||||
| G. leopoldii | 2.4 | 1.0–5.7 | 2.8 | 1.1–6.9 | 2.0 | 1.0–3.7 | 2.2 | 1.2–4.2 |
| G. piotii | 0.8 | 0.3–1.9 | 0.8 | 0.3–1.8 | 0.6 | 0.3–1.0 | 0.6 | 0.3–1.0 |
| G. swidsinskii | 0.6 | 0.2–1.4 | 0.6 | 0.2–1.4 | 0.7 | 0.4–1.2 | 0.7 | 0.4–1.2 |
| G. vaginalis | 0.8 | 0.4–1.9 | 0.8 | 0.4–1.9 | 1.3 | 0.7–2.3 | 1.2 | 0.7–2.3 |
| Any STI | 1.3 | 0.2–5.4 | 1.5 | 0.2–6.4 | 0.9 | 0.2–3.2 | 1.2 | 0.2–4.5 |
All logistic regression analyses with Firth'ss correction adjusted for gestational age. Only including participants with a pregnancy that progressed beyond 16 weeks of gestation. a Multivariate analyses are adjusted for ethnicity (White European/non-White European), body mass index (continuous) and smoking (no/yes or stopped during pregnancy). Statistically significant data (p < 0.05) are presented in bold.