Table 3.
Results of Causal Mediation Analysis with Non-compliance to TB treatment Compliance as Mediator between Sex and Sputum Conversion in the Cohort of Newly Diagnosed Pulmonary TB patients at Chennai, South India.
| Effect | Exposure | Odds Ratio (95 % CI)* | P-value | Bias-corrected CIs |
|---|---|---|---|---|
| Marginal Total Effect (MTE) of Sex on Sputum positivity at the end of intensive phase | Females | 6.77 (1.93–23.73) | 0.003 | 1.83–29.00 |
| Males | Ref | – | – | |
| Direct Effect of Sex on Sputum positivity at the end of intensive phase | Females | 3.42 (1.15–10.22) | 0.03 | 1.33–12.48 |
| Males | Ref | – | – | |
| Indirect Effect of Sex on Sputum positivity via treatment compliance during intensive phase | Females | 1.98 (1.08–3.62) | 0.03 | 1.06–3.44 |
| Males | Ref | – | – | |
| Effect of Sex on Non-compliance to TB treatment during the intensive phase | Females | 2.35 (1.09–5.08) | 0.03 | [Not Applicable] |
| Males | Ref | – | ||
| Effect of Treatment compliance on Sputum positivity at the end of intensive phase | Non-compliant | 199.11 (42.80–926.24) | <0.001 | |
| Compliant | Ref | – |