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(a) Kinome selectivity (KINOMEscan, Eurofins DiscoverX) for compound 10 at 1 μM concentration; 7 out of 403 kinases were inhibited with S(10) selectivity scores40 of 0.017. (b) X-ray cocrystal structure of 10 (magenta; PDB 8TU3) bound to the kinase domain of human BTK. Hydrogen bond interactions are shown as dotted lines.
