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Reagents, conditions, and yields (a) 4 N HCl in dioxanes, CH3CN, 90 °C, 16 h, 93%; (b) benzyl mercaptan, xantphos, Pd2dba3, DIPEA, dioxane, toluene, 90 °C, 6 h, 90%; (c) NCS, acetic acid, water, 0 °C, 5 h, rt, 5 h, 49%; (d) 30, pyridine, CH2Cl2, 1 h, 55%; (e) 2-morpholinoethan-1-ol, NaH, THF, rt, 1 h, 130 °C, 1.5 h, 40%.
