Table 4. Quinazolinedione Replacement.

^aPerformed at pH 6.8 using a monopotassium phosphate buffer system.

^cPK in male Sprague–Dawley rats dosed at 0.5 mg/kg IV using 100% DMSO formulation vehicle.

^dRat in vivo clearance.

^eRat in vivo half-life.

^fRat in vivo volume of distribution.

^gPlasma protein binding, rat.

^hNT = Not tested.