Table 1.
Results of blood gas analysis, cardiorespiratory variables and body temperature for nine cats after administration of alfaxalone (1 mg/kg), butorphanol (0.2 mg/kg), dexmedetomidine (5 μg/kg) (ADB) and 8/9 cats after ketamine (5 mg/kg), butorphanol (0.2 mg/kg), dexmedetomidine (5 μg/kg) (KDB)
| Variable | Treatment | Baseline | Time after drug administration (mins) |
|||||
|---|---|---|---|---|---|---|---|---|
| 5 | 10 | 15 | 20 | 25 | 30 | |||
| PaO2 (mmHg) | ADB KDB |
97.2 ± 9.7 99.3 ± 12.1 |
85.7 ± 16.8 72.8 ± 15 * |
81.5 ± 6.7
*
a
70.6 ± 9.5 * b |
86 ± 8.7a
70.6 ± 10.4 * b |
80.4 ± 5.1
*
71.9 ± 13.2 * |
82 ± 7.9
*
73.5 ± 14.8 * |
80 ± 7.0
*
76.9 ± 10.9 * |
| PaCO2 (mmHg) | ADB KDB |
29.7 ± 6.2 29 ± 4.8 |
30.7 ± 6.2a
36.8 ± 1.8 * b |
31.7 ± 3a
39.2 ± 5.3 * b |
32.7 ± 4.6 38.4 ± 7.4 * |
33.7 ± 3.1
*
40.2 ± 6.2 * |
34 ± 4.5 40 ± 6.8 * |
35.3 ± 5.6
*
38.2 ± 4.9 * |
| SpO2 | ADB KDB |
91.4 ± 4.8 92.7 ± 6.1 |
93.3 ± 3.5 90.3 ± 4.3 |
90.6 ± 4.6 87.8 ± 2.6 |
92.1 ± 5.2 90.1 ± 2.5 |
88.7 ± 8.1 90.1 ± 4.5 |
87.2 ± 8.9 90.7 ± 4.1 |
|
| MAP (mmHg) | ADB KDB |
120 ± 7.3 120.8 ± 10.6 |
124.3 ± 6.6 112.5 ± 5.6 |
118.9 ± 6.8 113.3 ± 14.7 |
116.9 ± 8.8 111 ± 14.8 |
115.9 ± 9 112.1 ± 12 |
116.6 ± 10.7 113.9 ± 9.5 |
112 ± 10.8
*
111.5 ± 10 |
| SAP (mmHg) | ADB KDB |
134.5 ± 6.6 137 ± 19 |
132 ± 5.4 123 ± 18.7 |
128.1 ± 7.5 128 ± 20.9 |
127 ± 9.7 125 ± 15 |
124 ± 10 127 ± 10.5 |
125.3 ± 10.9 128.9 ± 8.4 |
123.4 ± 12.9 129 ± 6.2 |
| DAP (mmHg) | ADB KDB |
110 ± 8.2 108 ± 6.4 |
118 ± 7.8 105.1 ± 16.4 |
111 ± 7.2 105.3 ± 16.5 |
108.5 ± 8.6 101.8 ± 16.7 |
108.9 ± 10.5 102.3 ± 14.5 |
108.9 ± 12.9 102.7 ± 11.3 |
103 ± 8.7
*
99.6 ± 12.1 |
| HR (beats/min) | ADB KDB |
201 ± 31 205 ± 39 |
161 ± 45
*
170 ± 33 * |
147 ± 32
*
157 ± 28 * |
142 ± 25
*
157 ± 37 * |
139 ± 24
*
154 ± 32 * |
138 ± 25
*
154 ± 31 * |
143 ± 24
*
154 ± 38 * |
| RR (breaths/min) | ADB KDB |
64 ± 26 53 ± 16 |
37 ± 12*
36 ± 13* |
37 ± 5*
30 ± 10* |
41 ± 5 34 ± 12 |
37 ± 7 30 ± 7 |
38 ± 9*
31 ± 6* |
39 ± 9*
33 ± 7* |
| Temperature (ºC) | ADB KDB |
38.1 ± 0.4 37.8 ± 0.6 |
37.9 ± 0.4 38 ± 0.7 |
38.2 ± 0.4 38.1 ± 0.7 |
37.9 ± 0.6 38.3 ± 0.6 |
37.9 ± 0.6 38.2 ± 0.5 |
37.9 ± 0.5 38.1 ± 0.6 |
37.8 ± 0.5 37.9 ± 0.6 |
Data are given as mean ± SD
Significantly (P ⩽0.05) different from baseline value
In each column, values with different superscript letters are significantly (P <0.05) different
PaO2 = partial pressure of oxygen in arterial blood; PaCO2 = partial pressure of carbon dioxide in arterial blood; SpO2 = blood oxygen saturation; MAP = mean arterial pressure; SAP = systolic arterial pressure: DAP = diastolic arterial pressure; HR = heart rate; RR = respiratory rate