Table 1.

Candidate prognostic indicators for survival to hospital discharge in 101 cats with histoplasmosis treated with antifungal therapy

Candidate indicator	Survivors (n = 89)	Non-survivors (n = 12)	P value
Clinical findings
Age (years)	6.1 (5.0)	8.0 (9.0)	0.31
Weight (kg)	3.4 (1.4)	3.5 (1.9)	0.51
Duration of clinical signs (weeks)	7.0 (17.0)	2.5 (5.8)	0.24
Weight loss (% with sign)	87	92	1.0
Diarrhea (% with sign)	12	8	1.0
Dyspnea (% with sign)	53	92	0.02
Lameness (% with sign)	18	0	0.21
Adventitial lung sounds (% with finding)	30	83	<0.001
Lymphadenopathy (% with finding)	34	33	0.17
Abdominal organomegaly (% with finding)	25	42	0.30
Cutaneous lesions (% with finding)	18	8	0.32
Joint effusion (% with finding)	10	0	0.59
Body temperature (ºF)	102.1 (1.9)	101.8 (1.2)	0.27
Respiratory rate (breaths/min)	44 (28)	54 (32)	0.80
Form (% with form)*	74/18/8	83/17/0	0.59
Neurologic disease (% with finding)	3	8	0.40
Fungemia (% with finding)	2	50	<0.001
Thrombocytopenia (% with finding)	46	57	0.70
Multiple cytopenias (% with finding) †	21	33	0.46
Treatment
Initial antifungal treatment (% fluconazole)	44	33	0.55
Fluconazole start dose (mg/kg/day)	14.6 (11.0)	20.3 (5.5)	0.72
Itraconazole start dose (mg/kg/day)	10.0 (1.2)	10.0 (0.6)	0.93
Glucocorticoid treatment (% received)	45	67	0.05
Glucocorticoid dose (mg/kg/day) ‡	0.75 (0.52)	0.60 (0.8)	0.64
Oxygen supplementation (% required)	21	83	<0.001

Values in bold are P ⩽0.05. Data are median (interquartile range [75th percentile–25th percentile]) or n (%), unless otherwise indicated

^*Disseminated/respiratory/gastrointestinal

^†Defined as at least two of the following: anemia, neutropenia, thrombocytopenia

^‡Prednisolone dose or prednisolone equivalent (dexamethasone dose • 7)