Table 6.
Biochemistry analysis and complete blood count data in relation to survival to 6 months after diagnosis in 94 cats with histoplasmosis treated with antifungal therapy
| Variable | Survival status | Median (IQR) | <Lower reference limit | ⩽Half lower reference limit | >Upper reference limit | ⩾Twice upper reference limit |
|---|---|---|---|---|---|---|
| WBC count (103/μl) | Yes | 10.1 (7.5) | 7/62 (11%) | 1/62 (2%) | 9/62 (15%) | 1/62 (2%) |
| No | 6.3 (10.7) | 3/31 (10%) | 2/32 (6%) | 3/31 (10%) | 1/31 (3%) | |
| P = 0.132 | P = 0.257 | P = 0.745 | P = 1.0 | |||
| Segmented neutrophil count (103/μl) | Yes | 6.7 (6.5) | 5/62 (8%) | 2/62 (3%) | 15/62 (24%) | 0/62 (0%) |
| No | 4.7 (5.6) | 8/31 (26%) | 2/31 (6%) | 7/31 (23%) | 2/31 (6%) | |
| P = 0.028 | P = 0.598 | P = 1.0 | P = 0.109 | |||
| Band neutrophil count (/μl) | Yes | 0 (160) | NA | NA | 10/63 (16%) | 3/63 (5%) |
| No | 80 (200) | 7/31 (23%) | 2/31 (6%) | |||
| P = 0.570 | P = 1.0 | |||||
| Lymphocyte count (103/μl) | Yes | 2.8 (2.4) | 9/63 (14%) | 2/63 (3%) | 0/63 (0%) | NA |
| No | 1.5 (1.5) | 13/30 (43%) | 4/30 (13%) | 2/30 (7%) | ||
| P = 0.004 | P = 0.083 | P = 0.102 | ||||
| Eosinophil count (/μl) | Yes | 140 (340) | NA | NA | 3/61 (5%) | 1/61 (2%) |
| No | 0 (200) | 0/31 (0%) | 0/31 (0%) | |||
| P = 0.548 | P = 1.0 | |||||
| Hematocrit (%) | Yes | 28 (13) | 31/63 (49%) | 2/63 (3%) | 1/63 (2%) | NA |
| No | 23 (18) | 19/31 (61%) | 4/31 (13%) | 0/22 (0%) | ||
| P = 0.283 | P = 0.090 | P = 1.0 | ||||
| Albumin (g/dl) | Yes | 2.9 (0.6) | 20/61 (33%) | 0/61 (0%) | NA | NA |
| No | 2.6 (0.8) | 12/31 (39%) | 1/31 (3%) | |||
| P = 0.646 | P = 0.337 | |||||
| Globulin (g/dl) | Yes | 4.3 (1.1) | NA | NA | 9/59 (15%) | NA |
| No | 4.2 (1.0) | 3/31 (10%) | ||||
| P = 0.534 | ||||||
| ALT (IU/l) | Yes | 39 (32) | 1/62 (2%) | NA | 3/62 (5%) | 1/62 (1%) |
| No | 37 (36) | 2/31 (6%) | 3/31 (10%) | 1/31 (3%) | ||
| P = 0.257 | P = 0.396 | P = 1.0 | ||||
| ALP (IU/l) | Yes | 26 (24) | 4/61 (7%) | NA | 2/61 (3%) | NA |
| No | 27 (20) | 1/31 (3%) | 1/31 (3%) | |||
| P = 0.660 | P = 1.0 | |||||
| Creatinine (mg/dl) | Yes | 1.0 (0.5) | 8/62 (13%) | 0/62 (0%) | 2/62 (3%) | NA |
| No | 0.9 (0.5) | 7/31 (23%) | 1/31 (3%) | 1/31 (3%) | ||
| P = 0.246 | P = 0.333 | P = 1.0 | ||||
| BUN (mg/dl) | Yes | 19 (8) | 11/61 (18%) | NA | 3/61 (5%) | 0/61 (0%) |
| No | 21 (11) | 3/31 (10%) | 4/31 (13%) | 2/31 (6%) | ||
| P = 0.369 | P = 0.220 | P = 0.111 | ||||
| Cholesterol (mg/dl) | Yes | 122 (61) | 5/50 (10%) | NA | 0/50 (0%) | NA |
| No | 135 (89) | 0/31 (0%) | 2/31 (6%) | |||
| P = 0.151 | P = 0.143 | |||||
| Creatinine kinase (IU/l) | Yes | 183 (159) | 3/39 (8%) | NA | 2/49 (4%) | 0/49 (0%) |
| No | 243 (454) | 0/27 (0%) | 5/27 (19%) | 2/27 (7%) | ||
| P = 0.548 | P = 0.090 | P = 0.123 | ||||
| Bilirubin (mg/dl) | Yes | 0.2 (0.2) | NA | NA | 7/58 (12%) | 5/58 (9%) |
| No | 0.4 (0.7) | 15/31 (48%) | 8/31 (26%) | |||
| P <0.001 | P = 0.055 | |||||
| Total calcium (mg/dl) | Yes | 9.3 (1.0) | 2/58 (3%) | NA | 1/58 (2%) | NA |
| No | 9.2 (0.9) | 4/31 (13%) | 0/31 (0%) | |||
| P = 0.177 | P = 1.0 |
Values in bold are P ⩽0.05
IQR = interquartile range; WBC = white blood cell; NA = not available; ALT = alanine transaminase; ALP = alkaline phosphatase; BUN = blood urea nitrogen