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. 2024 Apr;21(2):115–134. doi: 10.36131/cnfioritieditore20240201

Table 2. Neurobiology of resilience. Experimental studies.

2.a. Genetics

Authors and year Country Sample Materials and methods Findings
Mesquita et al., 2015 Portugal Human sample (220 children)
  • -Investigation of 5-HTTLPR and BDNF polymorphisms

  • -Assessment through the DAI

Higher indiscriminate behaviour in s/s homozygotes of 5-HTTLPR, if institutionalized
Sweitzer et al., 2013 USA Human sample (546 volunteers)
  • -DRD4 genotype

  • -Computerized delay discounting

  • -SES

Bidirectional association of DRD4 genotype with temporal discounting, conditioned by participants’ early life circumstances, according to the “differential susceptibility” model

BDNF= brain-derived neurotrophic factor; DAI= disturbances of attachment interview; DRD4= dopamine D4 receptor; SES= socioeconomic status.