Figure 4.

Effects of erastin on the regulation of GPX7 overexpression in inflammation and ECM degradation. (A) The transfected cells were pretreated with erastin followed by treatment with IL-1β. ELISA was used to determine the effects of erastin on the levels of inflammatory factors. (B) Western blot analysis was used to determine the effects of erastin on ECM degradation. *P<0.05, **P<0.01 and ***P<0.001. GPX7, glutathione peroxidase 7; ECM, extracellular matrix; oe, overexpression; NC, negative control.