Figure 5.

Comparison of population risk-based prevention with personalized prevention strategies using coronary computed tomography angiography. Differences in a population-based approach based on risk factors (e.g. commonly used ASCVD risk scores) and a personalized care strategy based on the actual disease phenotype observed with CCTA. In a population-based risk factor strategy, patients are treated based on the presence of risk factors. If the presence of risk factors aligns with the presence of atherosclerosis, patients are treated appropriately. In a population-based risk factor strategy, patients without risk factors but with presence of atherosclerosis are missed, while patients with risk factors but without atherosclerosis (above a certain age threshold) are unnecessarily treated. In a personalized care strategy with CCTA, patients can receive appropriate therapy based on their individual atherosclerosis phenotype. ASCVD, atherosclerotic cardiovascular disease; CCTA, coronary computed tomography angiography; Tx, treatment