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Biodistribution of intravenously administered Cas9-loaded PEGDB–PSiNPs. (a) Experimental scheme. Muscles were injured with barium chloride 2 days before intravenous treatment with PSiNPs containing fluorescently labeled Cas9. (b) Qualitative image of biodistribution of Cas9 loaded within PSiNPs. (c) Quantification of Cas9 fluorescent signal distribution by percentage of total signal. All error bars are standard deviation. Each data point represents one organ.
