Figure 8.

Systemically administered PSiNPs gene edit in BaCl₂ injured muscle. (a) Experimental strategy outline. (b) Quantification of tdTomato signal (gene editing) from healthy and BaCl₂-injured TA muscle and (c) representative IVIS images. (d) Indel detection by amplicon analysis (IDAA) data from the high dose in the intravenous dose response study. (e) Quantification of tdTomato IVIS signal (gene editing) from major organs excised from Ai9 mice in the intravenous dose response study. All error bars are standard deviation, and each data point represents one organ. Statistical comparisons using Šídák multiple comparisons, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001.