Table 2.

The association between metabolic syndrome components and age acceleration in years (GrimAgeAA).

	Model 1			Model 2			Model 2 + medication
	β	b (95% CI)	p-value	β	b (95% CI)	p-value	β	b (95% CI)	p-value
Waist circumference (cm)	0.235	0.060 (0.028, 0.091)	2.6E-4	0.092	0.023 (−0.009, 0.054)	0.154
HDL cholesterol (mmol/L)	−0.231	−1.919 (−1.156, −0.006)	0.001	−0.076	−0.631 (−1.558, 0.296)	0.181	−0.076	−0.631 (−1.560, 0.298)	0.182 µ
Triglycerides (mmol/L)∞	0.218	1.660 (−2.947, 3.042)	2.6E-4	0.081	0.618 (−0.185, 1.421)	0.130	0.081	0.618 (−0.187, 1.423)	0.131µ
Fasting glucose (mmol/L)∞	0.163	4.946 (0.567, 9.326)	0.027	0.062	1.830 (−1.615, 5.274)	0.296	0.062	1.832 (−1.617, 5.282)	0.296α
Systolic bp (mmHG)	−0.001	−0.000 (−0.027, 0.027)	0.990	−0.008	−0.002 (−0.024, 0.021)	0.890	−0.010	−0.002 (−0.024, 0.021)	0.868π
Diastolic bp (mmHG)	0.095	0.029 (−0.016, 0.074)	0.209	0.021	0.006 (−0.033, 0.045)	0.748	0.020	0.006 (−0.034, 0.045)	0.772π

Model 1 adjusted for family relatedness, age and sex, (age*sex).

Model 2 adjusted for family relatedness, age, sex, (age*sex), smoking status, alcohol consumption and physical activity.

HDL, high-density lipoprotein, bp, blood pressure.

^µuse of cholesterol lowering medications, ^αuse of blood glucose lowering medications, ^πuse of antihypertensives, ^∞natural log transformation was performed due to skewed distribution of variable.

One sample excluded for extreme log-transformed fasting glucose (mmol/L) value of over 2.75.

β standardized regression coefficient, b unstandardized regression coefficient, CI confidence interval.