Table 1.
Characteristics of included infants
| Extremely Preterm Neonatesa, b (n = 33) | |
|---|---|
| Perinatal/Postnatal Characteristics | |
| Female | n = 16 |
| Male | n = 17 |
| GA at Birth (weeks + days)c | 26 + 1, SD = 0 + 3 |
| Vaginal Delivery | n = 3 |
| Caesarean Delivery | n = 30 |
| Birth Weight (gram)c | 833, SD = 242 |
| Singleton Pregnancy | n = 21 |
| Multiple Pregnancy | n = 12 |
| Surfactant Received | n = 33 |
| Retinopathy of Prematurity | n = 15 |
| Bronchopulmonary Dysplasia | n = 6 |
| Necrotizing Enterocolitis | n = 2 |
| Patent Ductus Arteriosus | n = 4 |
| Perinatal Asphyxiad | n = 8 |
| PMA at MRI (weeks + days)c | 37 + 2, SD = 1 + 3 |
| Neonatal Mortality Assessment | |
| CRIB II Scorec | 11, SD = 3 |
| Maternal Characteristics | |
| Age at Delivery (years)c | 32, SD = 5 |
| Preeclampsia | n = 7 |
| Intra-Amniotic Infection (Chorioamnionitis)e | n = 4 |
| Gestational Diabetes Mellitus | n = 1 |
| Assessment of Neurodevelopmental Outcomes at 12 Months Corrected-Age | |
| Cognitive Outcome Scoresc, g | 94, SD = 16 |
| Language Outcome Scoresc, g | 99, SD = 12 |
| Motor Outcome Scoresc, g | 94, SD = 14 |
CRIB Clinical Risk Index for Babies, GA Gestational age, MRI Magnetic resonance imaging, PMA Post-menstrual age
a Studied infants have been reported previously (MDME- and DTI-based data). However, these investigations focused on different research objectives9,10,21
b Born at < 28 weeks of gestation
c Data presented as mean accompanied by standard deviation (SD)
d Based on Apgar scores, umbilical cord pH, first blood gas analysis (pH, base excess, and lactate), and clinical presentation (no evidence/absence of asphyxia-related brain injury)
e Based on placental histology, bacterial culture, inflammatory markers, and clinical presentation