Table 1.
Recipient-, donor-, and transplant-related characteristics of patients receiving a LT for HCC on cirrhosis vs. uncommon tumoral disease
| Variables | HCC on cirrhosis (n = 274) | Other tumors (n = 33) | P |
|---|---|---|---|
| Median (Q1–Q3) or n (%) | |||
| Recipient | |||
| Age, years | 59 (52–63) | 44 (40–55) | < 0.0001 |
| Male sex | 242 (88.3) | 16 (48.5) | < 0.0001 |
| Period of transplantation | |||
| 1982–89 | 1 (0.4) | 2 (6.1) | |
| 1990–99 | 38 (13.9) | 29 (87.9) | < 0.0001 |
| 2000–09 | 96 (35.0) | 1 (3.0) | |
| 2010–19 | 107 (39.1) | 0 (–) | |
| 2020–23 | 32 (11.7) | 1 (3.0) | |
| Group | |||
| 0 | 135 (49.3) | 14 (42.4) | |
| A | 102 (37.2) | 14 (42.4) | 0.91 |
| B | 22 (8.0) | 3 (9.1) | |
| AB | 15 (5.5) | 2 (6.1) | |
| Caucasian ethnicity | 265 (96.7) | 32 (97.0) | 1 |
| Underlying liver disease | |||
| HCV | 139 (50.7) | 1 (3.0) | < 0.0001 |
| HBV | 58 (21.2) | 1 (3.0) | 0.009 |
| Alcohol | 85 (31.0) | 0 (–) | < 0.0001 |
| NASH/cryptogenic | 30 (10.9) | 0 (–) | 0.06 |
| Acute liver failure | 1 (0.4) | 1 (3.0) | 0.2 |
| No underlying liver disease | 0 (–) | 31 (93.9) | < 0.0001 |
| Donor | |||
| Age, years | 50 (34–64) | 27 (18–43) | < 0.0001 |
| Male sex | 139 (50.7) | 19 (57.6) | 0.47 |
| Group | |||
| 0 | 142 (51.8) | 19 (57.6) | |
| A | 101 (36.9) | 11 (33.3) | 0.7 |
| B | 22 (8.0) | 3 (9.1) | |
| AB | 9 (3.3) | 0 (–) | |
| Transplantation | |||
| Split liver | 2 (0.7) | 0 (–) | 1 |
| Living donation | 6 (2.2) | 0 (–) | 1 |
| Multivisceral | 2 (0.7) | 2 (6.1) | 0.001 |
| Cluster | 0 (–) | 1 (3.0) | |
| Status UNOS 1-2A | 4 (1.5) | 4 (12.1) | 0.006 |
| Bypass and caval replacement | 105 (38.3) | 32 (97.0) | |
| Piggy-back | 17 (6.2) | 1 (3.0) | < 0.0001 |
| Piggy-back LL | 152 (55.5) | 0 (–) | |
| Total ischemia time, min | 450 (369–520) | 660 (540–780) | < 0.0001 |
HCC hepatocellular carcinoma, Q1–Q3 first-third quartile, HCV hepatitis C virus, HBV hepatitis B virus, NASH non-alcoholic steato-hepatitis, UNOS United Network for Organ Sharing, LL latero-lateral