Table 2.
Association between PD-L1 staining and clinicopathological features in CUP patients
| Clinical features | n | PD-L1 staining* | p-value | |
|---|---|---|---|---|
| Negative (%) | Positive (%) | |||
| Evaluable CUPs | 109 | 89 (81.7) | 20 (18.3) | |
| Age (years) | ||||
| < 60.4 | 53 | 40 (44.9) | 13 (65.0) | 0.100 |
| ≥ 60.4 | 56 | 49 (55.1) | 7 (35.0) | |
| Gender | ||||
| Male | 48 | 41 (46.1) | 7 (35.0) | 0.360 |
| Female | 61 | 48 (53.9) | 13 (65.0) | |
| Histology | ||||
| Adenocarcinoma | 65 | 52 (58.4) | 13 (65.0) | 0.840 |
| Carcinoma | 33 | 28 (31.5) | 5 (25.0) | |
| Squamous cell carcinoma | 11 | 9 (10.1) | 2 (10.0) | |
| Visceral metastasis | ||||
| Yes | 65 | 57 (64.0) | 8 (40.0) | 0.048 |
| No | 44 | 32 (36.0) | 12 (60.0) | |
| Dominant site of metastasis | ||||
| Visceral | 44 | 41 (46.1) | 3 (15.0) | < 0.001 |
| Lymph node | 29 | 20 (22.5) | 9 (45.0) | |
| Bone | 25 | 23 (25.8) | 2 (10.0) | |
| CNS | 4 | 2 (2.2) | 2 (10.0) | |
| Other | 7 | 3 (3.4) | 4 (20.0) | |
| Biopsy site (tissue analyzed) | ||||
| Liver | 35 | 33 (37.1) | 2 (10.0) | 0.003 |
| Lymph node | 32 | 20 (22.5) | 12 (60.0) | |
| Bone | 26 | 23 (25.8) | 3 (15.0) | |
| CNS | 4 | 2 (2.2) | 2 (10.0) | |
| Other | 12 | 11 (12.4) | 1 (5.0) | |
CNS: Central Nervous System; CPS: Combined Positive Score; (*) according to CPS and cutoff of 1 (1 up to 80)