Table 3.
Univariate and multivariate Cox regression analysis of overall survival in CUP patients
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (years) | ||||||
| < 60.4 | Ref | |||||
| ≥ 60.4 | 1.19 | 0.80–1.77 | 0.390 | |||
| Gender | ||||||
| Female | Ref | |||||
| Male | 1.12 | 0.75–1.67 | 0.560 | |||
| Histology | ||||||
| Adenocarcinoma | Ref | |||||
| Carcinoma | 0.86 | 0.55–1.35 | 0.510 | |||
| Squamous cell carcinoma | 0.80 | 0.40–1.57 | 0.510 | |||
| Visceral metastasis | ||||||
| No | Ref | Ref | ||||
| Yes | 1.8 | 1.19–2.72 | 0.005 | 1.43 | 0.94–2.19 | 0.100 |
| Dominant site of metastasis | ||||||
| Other | Ref | |||||
| Bone | 1.00 | 0.40–2.48 | 0.980 | |||
| Visceral | 1.45 | 0.61–3.46 | 0.390 | |||
| Lymph node | 0.68 | 0.27–1.67 | 0.400 | |||
| CNS | 0.83 | 0.23–2.99 | 0.780 | |||
| ECOG Performance Status | ||||||
| < 2 | Ref | Ref | ||||
| ≥ 2 | 2.65 | 1.67–4.20 | < 0.001 | 2.37 | 1.50–3.76 | < 0.001 |
| Unknown | 1.96 | 1.15–2.33 | < 0.001 | 1.69 | 0.98–2.90 | 0.060 |
| PD-L1 staining* | ||||||
| Negative | Ref | Ref | ||||
| Positive | 0.35 | 0.20–0.64 | < 0.001 | 0.42 | 0.23–0.76 | 0.0050 |
OS: Overall survival; CNS: Central Nervous System; (*) according to Combined Positive Score and cutoff of 1 (1 up to 80)