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. 2024 Apr 6;130(11):1758–1769. doi: 10.1038/s41416-024-02671-1

Fig. 4. Spatial location of CAF subsets in NSCLC.

Fig. 4

a Representative images showing staining patterns and locations of CAFs from each subset analysed; b Schematic showing markers used to distinguish CAFs in each subset; c Percentage of total CAFs identified as belonging in each subset across NSCLC subtypes; d Representative image showing that CAFs were identified in QuPath and then the distance to the nearest tumour region (demonstrated by the red arrows) for each CAF was calculated; e Distances to the nearest tumour region of each cell classed in each subset across all 163 patients. Stats shown from Tukey’s multiple comparisons test, ****p < 0.0001, nCAF-S1 = 60,002, nCAF-S4 = 123,075, nCAF-S5 = 17,179. All scale bars shown are 50 μm.