Table 2.

Association between physical frailty and risk of incident dementia.

			Model 1			Model 2
Frailty phenotype	Cases/ person-years	Incident cases per 100,000 person-years	HR (95% CI)	P	P for trend	HR (95% CI)	P	P for trend
Non-frailty	1,314/1,299,758	101.10	1 [Reference]			1 [Reference]
Prefrailty	1,639/977,109	167.74	1.452 (1.349–1.563)	<0.001	<0.001	1.396 (1.294–1.506)	<0.001	<0.001
Frailty	400/108,310	369.31	2.724 (2.426–3.058)	<0.001		2.304 (2.030–2.616)	<0.001

Model 1, adjusted for age, sex, education levels, Townsend deprivation index, and assessment centers.

Model 2, adjusted for model 1 plus alcohol intake, smoking status, body mass index, the number of long-term morbidities, polygenic risk score, genotyping array, and the first 40 principal components of ancestry.