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. 2024 May 27;10:37. doi: 10.1038/s41523-024-00644-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Representative images of NEDD8 (a) and SUMO1 (b) IHC in PDX tumor sections. Images shown are ×10 magnification, insets are ×20 magnification, and scale bars are 100 µm. c Bar chart showing PDX response to pevonedistat via normalized tumor to control ratios (T/C). Bars represent mean ± standard deviation. H-scores for NEDD8 (d) and SUMO1 (e) intensity, combining percent of tumor cells staining and intensity of staining. Images were quantified from three tumors per PDX model. Bars represent the mean ± SEM. f Dot plot showing the correlation of pevonedistat response (1-T/C) of SUMO1 H-Score (black) or NEDD8 H-score (Red). r = Spearman correlation coefficient, p = p value calculated from a two-tailed test.