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. 2024 May 14;15:1383664. doi: 10.3389/fpsyt.2024.1383664

Table 1.

MR analysis of the gut microbiota on PTMDD.

Classification Methods Nsnp Beta SE OR(95%CI) P value Horizontal pleiotropy Heterogeneity MR-PRESSO
Egger intercept SE P value Cochran’s Q P value outlier P value
Phylum Verrucomicrobia IVW 12 -0.224 0.079 0.799(0.684–0.933) 0.005 0.009 0.023 0.7 14.691 0.144 0 0.285
MR Egger -0.297 0.202 0.743(0.5–1.104) 0.172
Weighted median -0.259 0.096 0.772(0.639–0.932) 0.007
Simple mode -0.241 0.147 0.786(0.589–1.048) 0.129
Weighted mode -0.241 0.099 0.786(0.647–0.955) 0.033

MR, Mendelian randomization; PTMDD, Post-traumatic major depression disorder; Nsnp, Numbers of single nucleotide polymorphism; SE, Standard error; OR, Odds ratio; CI, Confidence interval; IVW, Inverse variance weighted.