Table 2.
MR analysis of PTMDD on the gut microbiota.
| Classification | Methods | Nsnp | Beta | SE | OR(95%CI) | P value | Horizontal pleiotropy | Heterogeneity | MR-PRESSO | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Egger intercept | SE | P value | Cochran’s Q | P value | outlier | P value | |||||||
| family Bacteroidales S24 7group |
IVW | 11 | -0.136 | 0.05 | 0.873 (0.791- 0.964) | 0.007 | 0.13 | 0.328 | 0.724 | 12.405 | 0.191 | 0 | 0.321 |
| MR Egger | -1.241 | 3.035 | 0.289 (0.001- 110.860) | 0.692 | |||||||||
| Weighted median | -0.129 | 0.065 | 0.879 (0.774- 0.999) | 0.047 | |||||||||
| Simple mode | -0.187 | 0.099 | 0.830 (0.684- 1.007) | 0.087 | |||||||||
| Weighted mode | -0.168 | 0.105 | 0.845 (0.688, 1.038) | 0.14 | |||||||||
| class Bacilli | IVW | 11 | 0.071 | 0.03 | 1.074 (1.011- 1.139) | 0.02 | -0.001 | 0.205 | 0.999 | 5.484 | 0.79 | 0 | 0.868 |
| MR Egger | 0.057 | 0.042 | 1.059 (0.976- 1.149) | 0.968 | |||||||||
| Weighted median | 0.045 | 0.06 | 1.046 (0.931- 1.177) | 0.171 | |||||||||
| Simple mode | 0.043 | 0.055 | 1.044 (0.937- 1.164) | 0.465 | |||||||||
| Weighted mode | 0.043 | 0.055 | 1.044 (0.937–1.164) | 0.453 | |||||||||
| genus Butyricimonas | IVW | 11 | 0.084 | 0.039 | 1.088 (1.009- 1.174) | 0.029 | 0.415 | 0.261 | 0.147 | 6.828 | 0.655 | 0 | 0.536 |
| MR Egger | -3.44 | 2.223 | 0.032 (0.000- 2.504) | 0.156 | |||||||||
| Weighted median | 0.141 | 0.054 | 1.151 (1.035–1.280) | 0.01 | |||||||||
| Simple mode | 0.162 | 0.097 | 1.176 (0.971–1.423) | 0.127 | |||||||||
| Weighted mode | 0.162 | 0.092 | 1.176 (0.981–1.409) | 0.11 | |||||||||
| order Lactobacillales | IVW | 11 | 0.066 | 0.03 | 1.068 (1.006–1.134) | 0.03 | -0.010 | 0.206 | 0.963 | 4.232 | 0.775 | 0 | 0.895 |
| MR Egger | 0.15 | 1.748 | 1.162 (0.038, 35.722) | 0.934 | |||||||||
| Weighted median | 0.057 | 0.038 | 1.059 (0.983- 1.141) | 0.132 | |||||||||
| Simple mode | 0.047 | 0.062 | 1.048 (0.929–1.182) | 0.465 | |||||||||
| Weighted mode | 0.044 | 0.054 | 1.045 (0.941–1.161) | 0.431 | |||||||||
| genus Howardella | IVW | 11 | -0.13 | 0.065 | 0.878 (0.773- 0.998) | 0.047 | 0.614 | 0.45 | 0.209 | 2.658 | 0.954 | 0 | 0.894 |
| MR Egger | -5.346 | 3.822 | 0.005 (0.000–8.547) | 0.199 | |||||||||
| Weighted median | -0.125 | 0.085 | 0.882 (0.746–1.043) | 0.142 | |||||||||
| Simple mode | -0.005 | 0.138 | 0.995 (0.759- 1.305) | 0.972 | |||||||||
| Weighted mode | -0.009 | 0.146 | 0.991 (0.745- 1.319) | 0.955 | |||||||||
MR, Mendelian randomization; PTMDD, Post-traumatic major depression disorder; Nsnp, Numbers of single nucleotide polymorphism; SE, Standard error; OR, Odds ratio; CI, Confidence interval; IVW, Inverse variance weighted.