Table 3.
MR analysis of trauma exposure in MDD on the gut microbiota.
| Classification | Methods | Nsnp | Beta | SE | OR(95%CI) | P value | Horizontal pleiotropy | Heterogeneity | MR-PRESSO | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Egger intercept | SE | P value | Cochran’s Q | P value | outlier | P value | |||||||
| family Verrucomicrobiaceae | IVW | 7 | 0.174 | 0.057 | 1.191 (1.066 - 1.33) | 0.002 | -0.346 | 0.172 | 0.101 | 2.504 | 0.776 | 0 | 0.387 |
| MR Egger | 2.937 | 1.375 | 18.861 (1.274 - 279.157) | 0.086 | |||||||||
| Weighted median | 0.2 | 0.075 | 1.221 (1.054 - 1.415) | 0.008 | |||||||||
| Simple mode | 0.223 | 0.124 | 1.25 (0.981 - 1.594) | 0.122 | |||||||||
| Weighted mode | 0.24 | 0.122 | 1.271 (1.002 - 1.613) | 0.096 | |||||||||
| order Verrucomicrobiales | IVW | 7 | 0.174 | 0.056 | 1.19 (1.065 - 1.329) | 0.002 | -0.346 | 0.172 | 0.101 | 2.496 | 0.777 | 0 | 0.43 |
| MR Egger | 2.937 | 1.375 | 18.856 (1.274 - 279.086) | 0.086 | |||||||||
| Weighted median | 0.199 | 0.076 | 1.221 (1.052 - 1.416) | 0.009 | |||||||||
| Simple mode | 0.223 | 0.129 | 1.25 (0.971 - 1.61) | 0.135 | |||||||||
| Weighted mode | 0.24 | 0.115 | 1.271 (1.014 - 1.593) | 0.083 | |||||||||
| class Verrucomicrobiae | IVW | 7 | 0.174 | 0.056 | 1.19 (1.065 - 1.329) | 0.002 | -0.346 | 0.172 | 0.101 | 2.496 | 0.777 | 0 | 0.412 |
| MR Egger | 2.937 | 1.375 | 18.856 (1.274 - 279.086) | 0.086 | |||||||||
| Weighted median | 0.199 | 0.076 | 1.221 (1.051 - 1.417) | 0.009 | |||||||||
| Simple mode | 0.223 | 0.125 | 1.25 (0.979 - 1.596) | 0.124 | |||||||||
| Weighted mode | 0.24 | 0.115 | 1.271 (1.015 - 1.591) | 0.081 | |||||||||
| genus Akkermansia | IVW | 7 | 0.174 | 0.057 | 1.19 (1.065 - 1.33) | 0.002 | -0.346 | 0.172 | 0.1 | 2.511 | 0.775 | 0 | 0.411 |
| MR Egger | 2.939 | 1.375 | 18.895 (1.276 - 279.694) | 0.086 | |||||||||
| Weighted median | 0.201 | 0.076 | 1.222 (1.054 - 1.418) | 0.008 | |||||||||
| Simple mode | 0.226 | 0.123 | 1.254 (0.986 - 1.594) | 0.115 | |||||||||
| Weighted mode | 0.241 | 0.126 | 1.272 (0.994 - 1.628) | 0.104 | |||||||||
| phylum Verrucomicrobia | IVW | 7 | 0.154 | 0.053 | 1.166 (1.051 - 1.294) | 0.004 | -0.322 | 0.168 | 0.115 | 2.138 | 0.83 | 0 | 0.496 |
| MR Egger | 2.721 | 1.346 | 15.196 (1.086 - 212.602) | 0.099 | |||||||||
| Weighted median | 0.155 | 0.078 | 1.168 (1.003 - 1.36) | 0.045 | |||||||||
| Simple mode | 0.097 | 0.114 | 1.102 (0.881 - 1.379) | 0.428 | |||||||||
| Weighted mode | 0.163 | 0.118 | 1.178 (0.934 - 1.485) | 0.217 | |||||||||
| order Victivallales | IVW | 7 | 0.238 | 0.086 | 1.268 (1.071 - 1.501) | 0.006 | 0.118 | 0.272 | 0.682 | 3.24 | 0.663 | 0 | 0.784 |
| MR Egger | -0.708 | 2.176 | 0.492 (0.007 - 35.017) | 0.758 | |||||||||
| Weighted median | 0.197 | 0.114 | 1.217 (0.974 - 1.521) | 0.084 | |||||||||
| Simple mode | 0.189 | 0.165 | 1.208 (0.875 - 1.669) | 0.295 | |||||||||
| Weighted mode | 0.17 | 0.145 | 1.185 (0.891 - 1.576) | 0.287 | |||||||||
| class Lentisphaeria | IVW | 7 | 0.238 | 0.086 | 1.268 (1.071 - 1.501) | 0.006 | 0.118 | 0.272 | 0.682 | 3.24 | 0.663 | 0 | 0.792 |
| MR Egger | -0.708 | 2.176 | 0.492 (0.007 - 35.017) | 0.758 | |||||||||
| Weighted median | 0.197 | 0.113 | 1.217 (0.975 - 1.52) | 0.083 | |||||||||
| Simple mode | 0.189 | 0.169 | 1.208 (0.867 - 1.683) | 0.306 | |||||||||
| Weighted mode | 0.17 | 0.139 | 1.185 (0.902 - 1.557) | 0.269 | |||||||||
| phylum Lentisphaerae | IVW | 7 | 0.237 | 0.086 | 1.268 (1.071 - 1.501) | 0.006 | 0.112 | 0.272 | 0.698 | 3.254 | 0.661 | 0 | 0.8 |
| MR Egger | -0.657 | 2.175 | 0.519 (0.007 - 36.803) | 0.775 | |||||||||
| Weighted median | 0.189 | 0.116 | 1.207 (0.961 - 1.517) | 0.105 | |||||||||
| Simple mode | 0.187 | 0.15 | 1.206 (0.899 - 1.619) | 0.258 | |||||||||
| Weighted mode | 0.17 | 0.137 | 1.185 (0.906 - 1.55) | 0.261 | |||||||||
| genus Candidatus Soleaferrea | IVW | 7 | -0.202 | 0.075 | 0.817 (0.705 - 0.946) | 0.007 | 0.253 | 0.238 | 0.337 | 2.929 | 0.711 | 0 | 0.658 |
| MR Egger | -2.22 | 1.902 | 0.109 (0.003 - 4.516) | 0.296 | |||||||||
| Weighted median | -0.193 | 0.107 | 0.825 (0.669 - 1.016) | 0.071 | |||||||||
| Simple mode | -0.186 | 0.143 | 0.83 (0.627 - 1.099) | 0.241 | |||||||||
| Weighted mode | -0.176 | 0.137 | 0.839 (0.641 - 1.097) | 0.247 | |||||||||
MR, Mendelian randomization; MDD, major depression disorder; Nsnp, Numbers of single nucleotide polymorphism; SE, Standard error; OR, Odds ratio; CI, Confidence interval; IVW, Inverse variance weighted.