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. 2024 May 22;138(10):599–614. doi: 10.1042/CS20231752

Figure 1. Experimental timeline illustrating study groups.

Figure 1

Rats were subjected to sham surgery or bilateral kidney ischemia-reperfusion (IR) for 45 min (time 0). End-points were set at 24 h (1 day) or 10 weeks (70 days) after reperfusion. Groups E, F, H and I received a single dose of miR-486-5p (0.5 mg/kg, IR+miR-486-5p) or scramble miRNA (0.5 mg/kg, IR+scb) by tail vein injection at the start of reperfusion. Groups G and J received two doses of miR-486-5p or scramble miRNA: the first dose on day 4 and second dose on day 21 of reperfusion. To the left of the figure, the number of animals in each group is shown in parentheses. The first number refers to the starting number of rats in each group while the second number indicates the rats that completed the study. Not shown in this timeline: a separate group of 10 rats received delayed miR-486-5p injection at 4 days after IR and were sacrificed at 5 days post-IR (group numbers included n=3 (sham), n=4 (IR), n=3 (IR+miR-486-5p)).