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. 2024 May 10;3(5):pgae187. doi: 10.1093/pnasnexus/pgae187

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© The Author(s) 2024. Published by Oxford University Press on behalf of National Academy of Sciences.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4. — Bioavailability, biodistribution, and biocompatibility of Cy7-labeled KM-CP^-met 24 h after oral gavage. A) Serum level of Cy7-labeled micelles in KM-CP^-met is the highest after oral delivery. B and C) Quantification of ex vivo organ Cy7 fluorescence levels show highest accumulation in the kidneys for KM-CP^-met and NT-CP^-met. D) H&E staining of organs shows no significant tissue damage or changes in morphology after all treatments (**P ≤ 0.01, ****P ≤ 0.0001, N = 4).