Table 2.
Multivariate regression analysis with interaction terms.
| Outcome | Subgroup factor | Divided standard | Numbers of studies | HR (95% CI) | p-value | Heterogeneity | Effects model | |
|---|---|---|---|---|---|---|---|---|
| I2 (%) | Phet | |||||||
| OS | Country | Italy | 1 | 1.98 (1.47–2.67) | <0.001 | – | – | FEM |
| Turkey | 2 | 1.74 (1.38–2.19) | <0.001 | 0.0 | 0.385 | FEM | ||
| USA | 2 | 2.38 (1.66–3.42) | <0.001 | 0.0 | 0.750 | FEM | ||
| China | 16 | 1.73 (1.49–2.02) | <0.001 | 62.3 | <0.001 | REM | ||
| Sample size | ≥200 | 13 | 1.70 (1.47–1.96) | <0.001 | 64.9 | 0.001 | REM | |
| <200 | 8 | 2.02 (1.66–2.45) | <0.001 | 14.5 | 0.317 | FEM | ||
| SII cut-off value | ≥900 | 5 | 2.22 (1.86–2.63) | <0.001 | 0.0 | 0.813 | FEM | |
| <900 | 16 | 1.65 (1.44–1.88) | <0.001 | 52.4 | 0.008 | REM | ||
| Analysis type | MVA | 20 | 1.81 (1.59–2.06) | <0.001 | 59.8 | <0.001 | REM | |
| UVA | 1 | 1.42 (0.90–2.25) | 0.135 | – | – | FEM | ||
| PFS | Country | Italy | 1 | 1.32 (1.05–1.67) | 0.019 | – | – | FEM |
| Turkey | 2 | 1.73 (1.40–2.13) | <0.001 | 4.2 | 0.307 | FEM | ||
| China | 6 | 2.21 (1.55–3.16) | <0.001 | 62.1 | 0.022 | REM | ||
| USA | 1 | 1.62 (1.07–2.46) | 0.023 | – | – | FEM | ||
| Japan | 1 | 0.38 (0.15–0.96) | 0.041 | – | – | FEM | ||
| Sample size | ≥200 | 3 | 1.69 (1.23–2.32) | 0.001 | 72.9 | 0.025 | REM | |
| <200 | 8 | 1.80 (1.27–2.53) | 0.001 | 68.8 | 0.002 | REM | ||
| Analysis type | MVA | 8 | 1.10 (0.71–1.72) | 0.671 | 70.6 | 0.033 | REM | |
| UVA | 3 | 1.91 (1.64–2.21) | <0.001 | 44.9 | 0.08 | FEM | ||
| SII cut-off value | ≥900 | 4 | 1.38 (0.84–2.26) | 0.2 | 81.0 | 0.001 | REM | |
| <900 | 7 | 1.92 (1.49–2.47) | <0.001 | 51.3 | 0.055 | REM | ||
FEM: Fixed-effects model; M: Multivariable; OS: Overall survival; PFS: Progression-free survival; REM: Random-effects model; U: Univariable.