Skip to main content
. Author manuscript; available in PMC: 2024 May 28.
Published in final edited form as: Osteoarthritis Cartilage. 2024 Jan 17;32(5):585–591. doi: 10.1016/j.joca.2023.11.024

Fig. 2.

Fig. 2

Associations between epigenetic age acceleration and hand, knee, and multi-joint OA. We calculated measures of epigenetic age acceleration based on Horvath, Hannum, PhenoAge, GrimAge epigenetic clocks, as well as intrinsic epigenetic age acceleration (IEAA) and extrinsic epigenetic age acceleration (EEAA). We then tested for associations between each of these measures (per year) and hand, knee, and multi-joint OA. All models were adjusted for chronological age, sex, clinical site, smoking status, and race. The forest plot reflects OR and corresponding 95% CI for each association.