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. 2024 Apr 28;16(4):e59210. doi: 10.7759/cureus.59210

Table 1. Summary of case reports on Fosmanogepix.

HSCT: Hematopoietic stem cell transplantation; HL: Hodgkin's lymphoma; GVHD: Graft-versus host disease; AML: Acute myeloid leukemia; FMGX: Fosmanogepix; AMB: Amphotericin B

Author (s) Case summary Duration of Therapy Outcome
Camargo et al. [40] A 40-year-old male who underwent HSCT for Hodgkin's lymphoma (HL) experienced complications with graft-versus-host disease (GvHD) and subsequently developed a disseminated infection with multi-drug-resistant Aspergillus calidoustus It is approximately 191 days, though it is not explicitly mentioned Significant improvement with negative serum galactomannan
Winston et al. [45] A 26-year-old with AML faced a Fusarium lactis infection, resistant to azoles and echinocandins. FMGX combined with liposomal AMB 6 months Clinical improvement, reductions in brain lesions, and an absolute neutrophil count rise, resulting in AML remission
Goggin et al. [46] A 14-year-old with immunodeficiency and end-stage kidney disease has had persistent cutaneous Fusariosis since age 3. Despite prior unsuccessful treatments, FMGX was successful, leading to negative skin biopsies 6 months Clinical improvement with negative skin biopsies