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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Arthritis Rheumatol. 2023 Jul 27;75(9):1586–1598. doi: 10.1002/art.42540

Figure 6. Restoration of lysosomal function prevents LAMP3-induced LMP and lysosome-dependent cell death in murine salivary glands.

Figure 6.

LAMP3-overexpressing mice received weekly subcutaneous injections of dulaglutide, an inducer of lysosomal biogenesis, at 0.6 mg/kg or placebo for 3 months after developing an SjD-like phenotype. (A) Immunofluorescent images of murine submandibular glands for galectin-3 (magenta) staining and bar chart showing the percentage of galectin-3 puncta-positive cells. (B) Immunofluorescent images of submandibular glands with terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL, red) and bar chart showing the percentage of TUNEL-positive apoptotic cells. (C) Hematoxylin and eosin staining of glands and the percentage of lymphocytic infiltration area in whole glands. (D) Pilocarpine-stimulated salivary flow per body weight in 20 minutes before and after treatment. (E) Serum anti-Ro/SS-A antibody levels. Original magnification: 40x (inset: 100x) for (A) and (B), and 4x for (C). Values shown are median and quartile (n = 9, each group). *p < 0.05, **p < 0.01, Wilcoxon test.