Table 4.
Univariate and multivariate Fine-Gray competing risk regression analysis for UTUC recurrence-free survival in patients with primary NMIBC.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HRs | 95% CI | P value | HRs | 95% CI | P value | |
| Age, years | ||||||
| <70 | 1 | |||||
| ≥70 | 0.80 | 0.32–2.00 | 0.64 | |||
| Sex | ||||||
| Male | 1 | |||||
| Female | 1.11 | 0.33–3.74 | 0.87 | |||
| Smoking history | ||||||
| Never | 1 | |||||
| Former/Current | 1.44 | 0.52–4.00 | 0.48 | |||
| Tumor size | ||||||
| ≤30 mm | 1 | 1 | ||||
| >30 mm | 2.86 | 1.17–6.97 | 0.021 | 2.53 | 1.04–6.15 | 0.040 |
| Multiplicity | ||||||
| Simple | 1 | |||||
| Multiple | 0.85 | 0.33–2.14 | 0.72 | |||
| Grade (WHO 2004) | ||||||
| Low grade | 1 | 1 | ||||
| High grade | 7.07 | 2.05–24.43 | 0.002 | 2.28 | 0.48–10.78 | 0.30 |
| CIS | ||||||
| Negative | 1 | 1 | ||||
| Positive | 8.02 | 3.09–20.81 | <0.001 | 4.78 | 1.48–15.42 | 0.0089 |
| Prostate-involving CIS | ||||||
| Negative | 1 | |||||
| Positive | 1.56 | 0.21–11.61 | 0.66 | |||
| LVI | ||||||
| Negative | 1 | |||||
| Positive | 2.23 | 0.80–6.20 | 0.12 | |||
| Variant | ||||||
| Negative | 1 | |||||
| Positive | 1.68 | 0.24–11.99 | 0.60 | |||
CIS: carcinoma in situ; HR, hazard ratio; LVI: lymphovascular invasion; NMIBC: nonmuscle invasive bladder cancer; PS: performance status; TURBT: transurethral resection of bladder tumor; UTUC: upper urinary tract urothelial carcinoma; WHO: World Health Organization.