Table 1.

Summary of phase I dose-finding designs for late-onset toxicities. TITE: Time to Event; CRM: Continual Reassessment Method; PRT: Predicted Risk of Toxicity; EM: Expectation Maximization; DA: Data Augmentation; EWOC: Escalation with Overdose Control; IR: Isotonic Regression; CDP: Conaway, Dunbar, and Peddada; BOIN: Bayesian Optimal Interval; POD-i: Probability of Decision interval; CFO: Calibration Free Odds.

Authors	Type of design	Method for pending data	Available software
Model-Based
Cheung & Chappell (2000)	TITE-CRM	Weighting scheme	R package dfcrm, R shiny TITE-CRM
Braun (2006)	Generalized TITE-CRM	Weighting scheme	None listed
Bekele et al. (2008)	PRT	Model predicted risk of toxicity	Windows software mdanderson.org
Mauguen et al. (2011)	TITE-EWOC	Weighting scheme	None listed
Yuan & Yin (2011)	EM-CRM	EM algorithm	None listed
Liu et al. (2013)	DA-CRM	Data augmentation process	Windows software mdanderson.org
Yin et al. (2013)	Fractional CRM	Kaplan-Meier estimator	R shiny fCRM, Github fCRM
Tighiouart et al. (2014)	EWOC-Time to toxicity	Cox proportional hazards model	Web tool EWOC
Zheng et al. 2016	Bayesian logistic model	Weighting scheme	None listed
Chapple et al. (2019)	TITE-IR	Weighting scheme	R package titeir
Andrillon et al. (2020)	Survival-CRM	Survival exponential model	Github SurvivalCRM
Zhu et al. (2021)	Rolling-CRM	Truncated piecewise exponential model	R package crmPack
Wages et al. (2023)	TITE-CDP	Weighting scheme	R shiny TITE-CDP
Model-Assisted
Yuan et al. (2018)	TITE-BOIN	Bayesian data imputation	R shiny TITE-BOIN
Lin & Yuan (2020)	TITE-Keyboard	Weighting scheme	R shiny TITE-KEYBOARD
Zhou et al. (2021)	Late onset BOIN	Poisson process	None listed
Xu & Lin (2022)	POD-i3+3	Weighting scheme	R Shiny podi3
Jin & Yin (2023)	TITE-CFO	Imputation potential outcomes	Github CFO