Table 3.
Health-state utilities and disutilities
| Base-case value | Sensitivity analysis values | Source | |
|---|---|---|---|
| Utilities | |||
| Prophylaxis | |||
| No bleeds | 0.866 | 0.825–0.906 | A-LONG and ASPIRE* |
| Any bleeds | 0.837 | 0.796–0.877 | A-LONG and ASPIRE* |
| On-demand | |||
| No bleeds | 0.721 | 0.680–0.761 | A-LONG and ASPIRE* |
| Any bleeds | 0.692 | 0.651–0.732 | A-LONG and ASPIRE* |
| Disutilities | |||
| Other bleed† | 0.039 | 0.030–0.050 | A-LONG and ASPIRE* |
| ICH bleed‡ | 0.400 | 0.320–0.480 | [41]§ |
| Change in utility with ≥ 1 year | − 0.008 | − 0.010 to − 0.004 | A-LONG and ASPIRE* |
| Joint (hip/knee) surgery | 0.010 | 0.008–0.012 | A-LONG and ASPIRE*, [32]§ |
ICH intracranial haemorrhage
*Unpublished post hoc analyses
†Disutility lasting for 7 days
‡Disutility lasting for 90 days
§Calculation based on data from the source references