Table 1.

Significant WGCNA gene module differential expression analysis for asthma

Module label	Hub gene		log2 FC	Adjusted p-value	# genes in module	# genes with DEG q < 0.05	Most signifiicant
	WGCNA	STRING					DEG in module
M6	CEACAM5	MET	0.32	9.62E−16	71	26	HS3ST4
M2	CPA3	POSTN	0.54	2.39E−14	81	45	PTCHD4
M5	DKK3	FN1	−0.28	7.63E−09	72	34	FN1
M20	C16orf89	RIMS1,PPP1R9A,NR2F1	−0.36	3.41E−08	33	14	PPP1R9A
M23	ACVR1B	CCND1	−0.16	4.56E−08	23	5	SUSD4
M15	SF3A1	SMARCA2	−0.06	1.61E−05	44	18	SPTBN1
M1	PDCD10	EEF1E1	0.07	3.74E−05	88	21	ETAA1
M4	IFT172	GLRB,NCALD,TP53BP1,PTPRT	−0.13	3.74E−05	77	17	SLC13A3
M3	ENSG00000279476	BCAN,PLAGL1,UGT1A1,PRRT2,GARNL3,CYP2A7	0.16	1.24E−04	78	15	ENSG00000273599
M21	POLD2	POLD2,UBB	−0.09	2.17E−04	31	11	GNAS
M9	DNAH10	DNAH5	−0.13	2.46E−04	58	15	DNAH5
M24	RPL7A	RPL23A	−0.08	2.29E−03	21	5	MT3
M14	SARS1	VCP	−0.05	2.58E−03	44	11	POFUT1
M11	ST13	HSP90AB1	−0.04	4.15E−03	48	9	FAM169A
M8	PRKCSH	ERBB2	−0.05	6.25E−03	62	18	VPS18
M10	ASPM	BIRC5,CCNA2	0.10	2.74E−02	48	11	PARPBP

Genes with q < 0.15 in full group DEG analysis for asthma (see Supplementary Table S1) were grouped into 24 modules using WGCNA. 24 modules were tested for association with asthma, and the 16 identified with q < 0.05 are shown in this table. Bold font indicates gene used to label the module in Fig. 2. Analysis was performed using a moderated t-statistic (two-sided).