Table 1.

IC₅₀ of Ru-TRZ hybrids in HCT116 and HT29 cells.

Ru-TRZ	IC50 (μM) HCT116	95% CI a	IC50 (μM) HT29	95% CIa
TRZ1	16.75	11.12–25.21	34.78	21.49–56.30
TRZ2	0.45	0.31–0.66	0.24	0.21–0.28
TRZ3	0.46	0.36–0.57	0.20	0.15–0.27
TRZ4	0.55	0.44–0.69	0.23	0.18–0.29
TRZ5	0.22	0.15–0.32	0.31	0.17–0.59
TRZ6	2.42	2.12–2.77	3.54	2.51–4.98
TRZ7	0.55	0.34–0.89	0.36	0.27–0.53
TRZ8	0.46	0.31–0.70	0.27	0.18–0.40
TRZ2-PEG	0.29	0.27–0.32	0.38	0.29–0.49
TRZ2-PEG-Fluo	0.30	0.28–0.33	0.48	0.38–0.62
TRZ7-Fluo	1.83	1.39–2.40	2.19	1.59–3.04

IC₅₀ determined by the MTS assay after 72 h of compound incubation. Each value is the mean of three independent experiments performed in duplicate.

^a95% confidence interval.