Table 2.
Cytotoxic activity of TRZ2, TRZ7, TRZ2-PEG and TRZ2-PEG-Fluo in HT29, HEPG2 and AML12 cells.
| Ru-TRZ | HT29 EC50 (μM) | 95% Cla | HEPG2 EC50 (μM) | 95% Cla | AML12 EC50 (μM) | 95% Cla |
|---|---|---|---|---|---|---|
| TRZ2 | 7.66 | 6.45–9.10 | 35.30 | 31.67–39.79 | 18.19 | 12.89–25.47 |
| TRZ7 | 15.20 | 12.15–19.09 | 16.75 | 14.52–19.32 | 40.22 | 24.30–115.4 |
| TRZ2-PEG | 5.85 | 3.88–8.69 | 2.19 | 0.91–4.14 | 27.05 | 2.512–61.57 |
| TRZ2-PEG-Fluo | 18.85 | 15.04–23.24 | 16.23 | 13.70–19.16 | 35.59 | 28.06–50.27 |
IC50 determined by AK release after 24 h compound incubation. Each value is the mean of three independent experiments performed in duplicate.
a95% confidence interval.