Table 3.
IC50 of TRZ2, 5-Fluorouracil (5-FU), Oxaliplatin (OX), Irinotecan (IRI), triple combination of 5-FU, OX, and IRI (FOXIRI) and drug combinations of TRZ2 and chemotherapeutics in HT29 cells after 24 h of incubation.
| Compound | IC50 (μM) | CI | Effect |
|---|---|---|---|
| TRZ2 | 7.66 | - | - |
| 5-FU | 29.95 | - | - |
| OX | 10.78 | - | - |
| IRI | 44.02 | - | - |
| FOXIRI | 12.80 | - | - |
| TRZ2 + 5-FU | 4.11 | 0.12 | Synergistic |
| TRZ2 + OX | 2.72 | 0.60 | Synergistic |
| TRZ2 + IRI | 6.75 | 1.89 | Antagonistic |
| TRZ2 + FOXIRI | 4.31 | 0.49 | Synergistic |
Table also displays the Combinatory Index (CI) values and associated effects (Synergistic or Antagonistic). CI < 0.8 depicts synergism between drugs, 0.8 < CI < 1.2 depicts additivity and CI > 1.2 depicts antagonism.